The Powerpuff Girls: Crossover War

The Powerpuff Girls: Crossover War is a Netflix animated action crossover thriller film directed by The Angry Birds Movie co-director Clay Kaytis. It will be released in 2023. It is produced by Cartoon Network Studios and distributed by Netflix. It is also the Cartoon Network's first collaboration with Netflix. It is a cartoony retelling of Powerpuff Girls Doujinshi, while also using elements from Unikitty!, The Loud House, Teen Titans Go!, Spider-Man: Into The Spider-Verse, Avengers: Infinity War, The Angry Birds Movie, Star vs. the Forces of Evil, The LEGO Movie 2: The Second Part, NFL Rush Zone, and others.

Synopsis
The Powerpuff Girls team up with Legion Loud, a creation by Kingpin, to save the world the Boov Officer Kyle

Plot
The movie begins with Marceline the Vampire Queen telling the prologue of the story to the audience. After she tells us how the Powerpuff Girls were formed, she tells us that an invasion called the Kingpin invasion was spreading.

Having acquired the Mind Stones, Kingpin (Wilson Fisk) and his lieutenants—Ebony Maw, Prowler, Kludd, and Creek—intercept Echo Creek carrying the last two survivors of Echo Creek's destruction. As they extract the other Mind Stones, Kingpin subdues Star Butterfly, overpowers Marco Diaz, and kills Janna. Kingpin also kills Kelly in order to acquire the Mind Stones. Marco tells Star to run so she can find some other place to live. Star kept running, but gets choked on the neck by Kingpin, who slices her right arm off, and drops her off the cliff. Blisstina Utonium found her unconscious body, and took her to the Powerpuff Girls.

Blossom, Bubbles, and Buttercup hear the news about the Kingpin invasion. Blossom had to call on Star Butterfly, but she didn't answer. It was confirmed that she lost her right arm when she was attacked in the invasion of Mewni. Professor Utonium arrives at their house with Star's corpse. The Girls bring her body to the lab. They find a robot arm that matches her original arm, and insert it on her right side. Star wakes up, and asks the Girls what had happened. The Girls tell her that she lost her right arm so they gave her a robot arm. Star felt happy with the robot arm. Blossom told Star that the cause of her parents' death was unknown. Star asks Bubbles why her parents died. Bubbles told her that somebody had killed them. Buttercup told her that it was because of an invasion called: the Kingpin invasion. The invasion was first targeted at Mewni. She also told her that the Kingpin invasion is spreading. The Girls task Star to join forces with Dr. Fox and keep her alive. Blossom develops a plan to stop the Kingpin invasion once and for all.

A day later, we cut to Lincoln Loud. He wakes up & notices the audience. He introduces himself & tries to introduce his sisters, but has to chase after the audience. When the audience gets to Lucy, she's desperately picking up her fortune-telling cards before running off. After he goes into Lisa's room, he notices Lisa's experiment is about to explode. He tries to run but the explosion is so powerful it blows him out of the house & into the garage & crash-lands on his girly bike. The bike & Lincoln go into the city fast. He tries to avoid people & accidentally destroys some stores, Flip's Food & Fuel & a few houses including the Tetherby residence. He goes through the sewage plant & national park. No one gets hurt though. After washing up onshore, he goes back home, puts the bike back in the garage & jumps through the hole where he was sent flying. The sisters do not know where Lincoln is, until he is catapulted into the hole and lands on the couch looking very tired.

The sisters have been asking where he's been especially, Lisa. He lies to them & says he landed in the backyard. He then talks to the audience saying: "I know! Sometimes a white lie works for everyone", only for his sisters to overhear this. He then goes to school & everyone has been saying about a destroyer who destroyed the town. Lincoln gets nervous & for the whole day of school, he denied anything about him being the destroyer. Meanwhile, Kingpin and his lieutenants arrive at Royal Woods, because of the incident. Later, Lincoln comes home to the sisters watching a news report. He gets even more nervous when the sisters say they want to kill the destroyer. He then turns the channel saying: "The news is not that interesting. I hear 90 percent of the news stories they tell aren't true!" He changes the channel to "Arrgh!" & after Lucy tells her siblings about how her cards told her that all their lives aren't going to be the same after the movie, a knock is at the door. He thinks it's Clyde so he gets the door, but it's not Clyde, it's Kingpin who wants to ask questions to Lynn & Rita. When Lincoln & his sisters tell him, they aren't home & explain that they're their kids; Kingpin is shocked, but manages to calm himself down & lies to them that he's Ben's kid. Before he leaves, he talks to them & secretly sabotages Lisa's experiment, while taking some files that Lisa found, only to be attacked by the Loud Kids & get tossed into a dumpster, with his lieutenants with him. Smiler arrives, and tells them that she wants to be on the winning team (Team Kingpin).

When Lincoln & his sisters ask about Kingpin to their parents, they say he was Ben's kid from a barnyard & gives them a document. After Lincoln tells the audience that nothing that Lucy said is going to come true & brings up that their records have gone missing, Lynn & Rita then nervously tell them the truth that they were supposed to have only 2 or 3 kids, not 10 or 11 as they explained the startling result, which leaves them shocked & speechless, causing all of them, except Lily, to laugh which quickly turns into maniacal laughter & then to screaming & causing them to cry like babies. Awhile later, showing the whole house as a mess and Lynn Sr. says to Rita "I knew they weren't going to take well, especially since they just found out about him." They then carry their unconscious bodies to bed, while Kingpin assembles his allies to help them get back at the Louds but first ruining their lives since he recorded their meltdown thanks to hidden cameras, which everyone in Bird Island and Piggy Island, including the Powerpuff Girls, watched on screens. It had the Loud kids’ reaction of the news. The next day, Lincoln, having got a hangover over what happened & then recovered, says "Darn it, I jinxed it!". He & his sisters refused to speak to each other as their parents take them to school. When they're at their schools though, Clyde & Ronnie ask Lincoln why did he give them an earful through the phone, when after Lincoln tells them he didn't do that, the schools hired some assemblies to show the Loud kids' meltdown, which thanks to Kingpin, have gone viral, to the tune of Niall Horan's "Finally Free", but eventually faint after taking their happy gummies laced with Xanax & a chandelier dropping on their heads, which causes everyone, but the Loud kids, to laugh, which causes them to destroy the projector and run away to the bathrooms to cry which they stay in there for the rest of the school day which is about 6 hours.

When they get back from school, though, they start to argue & verbally abuse each other about what just happened & accuse each other for recording their meltdown & begin fighting. Lynn Sr. & Rita see what happens. They slap their kids' faces when they keep arguing & called them a bad word, causing them to roar in anger, scream at the top of their lungs & go at each other. The Powerpuff Girls peek into the ongoing scene. Lynn Sr. & Rita, regretting what they just did, barricade themselves in the Sister Battle Protocol safe room. Besides the standard punching & kicking, there's also some of them being dragged around & Lily tossing dirty diapers like bombs: Lori punches Leni a couple times, but she grabs her & they both tumble down the stairs with Leni landing on her head. Luna blasts Luan with her music, but Luan then short-circuited the speakers, only for Luna to respond by whacking her with her guitar. Lynn hits Lucy a couple times with the living room table until Lucy grabs Lynn's fist, curls her into a human pretzel & throws her like a bowling ball into Lola & Lana. Lincoln tries to get Lisa out his head until he rams her into one of the walls, breaking her glasses. Then they start picking up the furniture & start hitting each other with it until Lincoln throws Lisa's tampered with chemicals, causing an explosion which destroys the house & Lynn Sr. & Rita's safe room. Birds start flying away startled as well as seen in space & everyone else hears the explosion & decide to check it out. This was also seen by the Powerpuff Girls, which, concerned with Kingpin’s plan, start calling on Emmet, Lucy, 2014 Unikitty, Benny, and MetalBeard to record a footage of an upcoming scene.

It cuts to a Breaking News with the anchorman talking about what happened & the news reporter interviewing some of the residents. When she interviews Lynn Sr. & Rita, Rita gets interrupted by the Loud kids in the distance before lunging at the parents, causing the news reporter to cut to technical difficulties. After going to a 1980s Coca-Cola commercial after learning the weather & sport equipment was damaged & the weather & sports are told, Tucker talks about Lincoln & his sisters giving out some information & telling about some of the terrible things they & their parents have done. He then learns that Royal Woods went into a town-wide brawl after one of Lincoln's classmates threw a drink at him to get them to stop beating their parents, which made Lincoln & his sisters go ballistic. This is confirmed when the reporter is shown trying to escape into his news van and the brawl is also shown from above by a police helicopter. The brawl gets so bad, curb-stomps litter the street, tear gas gets used & everyone gets dragged around or body-slammed. After it's all over, Lynn Sr & Rita get arrested & charged, the pets are captured by Animal Control & Lincoln & his sisters get sedated & sent to a juvenile delinquent facility. Lynn Sr. & Rita are then sent to another jail & everyone else is under house arrest & martial law is installed. Emmet, Wyldstyle, 2014 Unikitty, Benny, and MetalBeard, Blossom, Bubbles, and Buttercup came to watch Lincoln & his sisters, who are still arguing & fighting in the facility to the point they had to be separated. However, they're still filled with enough rage to break off the bars, defeat Rambamboo and the Tadpolice who came after hearing the bars break & escape the facility, which is soon reported by a bunch of news reports and talk shows.

Lori manages to make it the ruins of the house first & salvages her phone but deleting all calls & numbers off, some golf clubs & some clothes & food in one of Lynn's gym bags as well as taking Vanzilla with her. She brings Lily with her because she's too young to be alone, though she does lose her later after burning Vanzilla, not caring about her. The rest of the sisters and Lincoln salvage their stuff and prized possessions as they go their separate ways. They also hired their stunt doubles to throw everyone off their trails. Meanwhile, Clyde & the other members of the Rescue Team break Lynn Sr. & Rita out, buy Veronica back, and go on their way to find the Loud kids. They immediately find new lives and find it hard to adjust to the contents with Lynn ending up in the streets and Lucy writing a poem named Ice Demon as well as discovering that they got powers. Upon adjusting to their new lives & powers, they sing and dance in the midst of the fateful turn of events. Later that night, the kids have a shared nightmare about a seemingly homicidal fusion named Legion Loud and wake up in shock. While Red, Chuck, and Bomb sneak into the crime scene, the Loud kids then confront Kingpin and his army but they are wounded one by one: first Lisa, then Luna, Leni, Lily, Lori, Lola, Luan, Lana, Lynn, Lincoln & Lucy but not before they take down Kingpin's army & Lucy takes Kingpin down by smashing a droid near him with a crowbar as she is flown into a wall by Ebony Maw's powers and is wounded with the others. They die of their injuries and Emmet orders Lucy, 2014 Unikitty, Benny, and MetalBeard to go so he will stall them, making a strange sound. After Kingpin and his lieutenants notice that Emmet was there the whole time, he orders the Prowler to get him and kill him. When Emmet runs off, he is chased by the Prowler, and bumps other people to get away from the Prowler. The Prowler rides a motorcycle to easily grab him, but he escapes. After going through a car collision, Emmet looks at the ruins of the two vehicles and runs off with the Prowler watching him.

The rescue team (including Gabby) head back to Royal Woods and express their guilt from their actions towards them in previous episodes as they properly bury the Loud kids. However, a few moments later, Blossom, Bubbles, and Buttercup sneak in to watch Kingpin and his lieutenants dig the bodies out of their graves and promptly fuse their minds and bodies to become Legion Loud as her components' souls come back from beyond the grave and confirm that Legion's appearance in the Loud kids' shared dream wasn't really a dream but a future vision that Lucy predicted from earlier. A day later, Howard checks on Rita and Lynn on if they still miss their kids. They nod their heads and say that the worst part is that this movie is the series finale, causing everyone, including them, to panic & end up in a meltdown similar to the Loud kids video Kingpin put out. Kingpin & Legion, meanwhile, are watching this with the former laughing their butts off & the latter has war flashbacks to her components' meltdown & everyone laughing at her components. Kingpin stops laughing & notices Legion's face and asks if she's alright. Legion doesn't respond, which makes him think he might have injected Leni's autism into her body & facepalms & says "Dang it!". Legion then puts a thumb in her mouth & starts sucking on it. Kingpin then yells at one of his minions for putting too much baby traits in her & everyone starts arguing about this. Legion, who apparently hates seeing people arguing, uses Lincoln's powers to silence the group's voices & uses Luna's sonic scream in the process. The rescue gang hears it and goes to the source of the sound. This worries Kingpin, since it means that she also got the Loud kids' newly developed powers.

Getting the attention of the rescue crew, they arrive at the lair & confront the bad guys. Kingpin (who was able to get his voice returned by Legion) confronts Rita for dumping him & that Legion was part of the plan he had along. The others get confused before realizing that the serum that was injected into Rita in the past was the reason why she even had so many kids & that Legion was the Loud kids, scaring everyone & Legion, now thinking she's a monster because of that, starts crying, causing Kingpin to comfort her after telling his minions to get her a baby bottle, before siccing her on them. The gang then learns (not before getting hurt at least once) that they can stop Legion by calling back the Loud kids' memories. They call out as much moments as possible, though they doesn't stop them from getting hurt. Clyde was finally able to do it, not before getting choked on by Legion, by showing her the picture he took at the end of The Whole Picture. Legion takes a minute to look at it & Kingpin, seeing the photo, says "I'm out of here!" before a montage of the best moments of The Loud House appears. Legion was then able to have full memory on the kids. She turns to get revenge on Kingpin before realizing that he ran away without his minions. She & the rescue gang agree to do a manhunt for him & rent a really huge mansion to stay in until they defeat Kingpin.

While they look for Kingpin, the rescue gang learns a lot about Legion. A few examples being that she is sensitive to loud noises, has an eating disorder & likes giving real hard hugs. They also try to get some attention and love from her, which all fail since she has the Noise-B-Gone earplugs in her ears. In Frown Town, Master Frown and Brock meet her, but they don't hear anything until they notice her & read her mind, knowing what she wants to talk about. Legion hugs them, telling them how sorry she is for starting this whole mess. She says that if it weren’t for her components freaking out about being an experimental child, then none of this would've happened in the first place. Brock asks "If none of this would've happened in the first place, then why don't you shows us what's in your mind?" Master Frown nods. The touching moment doesn't last long as the radar that Ronnie used shows that Kingpin is out in the front of the house. Legion falls into a full throttle panic attack & puts a pacifier in her mouth, only for Kingpin' former minions to come in. They explain that they're helping them & apologize to Legion for how they antagonized her components. Legion forgives them and they head out to fight Kingpin, who killed Lynn Sr. and Rita and appears to look way worse than in the beginning of the movie.

Kingpin, now acting like a total maniac, blabs about how Legion abandoned him & that she's going to have to pay the price, despite Clyde saying he left her after she saw the picture. Kingpin then states that if Legion doesn't surrender, she will "get a beating". Legion refuses & everyone fights Kingpin, while Legion watches from inside, wondering on whether or not to help them.

Emmet attends a meeting with his friends back in Bricksburg. He shows them a footage of the Loud kids being wounded one by one. Lucy shows another footage of Lucy Loud getting flown into a wall. Matilda admits that the Powerpuff Girls and the others will deal with this situation. After a description of the incident by the Duplo Aliens, Balthazar goes on stage playing a harp, presenting a play about how the Loud kids died, and what they might do to stop the Kingpin invasion. When the play ends, everyone gets into applause, and everyone continues to enjoy the party.

The next day, Legion meets Blossom, Bubbles, and Buttercup, who guide her to Unikingdom. Legion sees the five friends in the kingdom. Unikitty introduces herself to Legion, and then she introduces Puppycorn, then Hawkodile, then Dr. Fox, and then Richard. She tells them that Kingpin's minions killed the Loud kids. Puppycorn explains that Kingpin had to find the Mind Stones to fuse 11 people into one person. Hawkodile says that Kingpin's lieutenants are Ebony Maw, Prowler, Kludd, Creek, and Smiler. Richard tells Legion that it happened days ago. Unikitty tells Legion that she already knew her first lieutenants Master Frown and Brock, who arrive to the group, and tell her that they saw Kingpin kill Lynn Sr. and Rita, too. Puppycorn says that the only way to restore harmony to the Tooniverse is to defeat Kingpin and his crew, and they will win. He also stated that if they win, all the cartoon universes will reset, and the Loud Kids will be alive again. Blisstina Francesa Francia Mariam Alicia Utonium is there, too. And also Beemo and Star Butterfly (who is wearing her light blue heart outfit and has a robotic right arm after she lost her original right arm in the Echo Creek invasion). The Girls also tell Dr. Fox to stay with Star Butterfly, and told Star to take care of her and she tells them that she will not fail to do it. The group leaves the two to use their magical scissors to cut to where they are. However, Hawkodile decides to stay in Unikingdom and warn the citizens.

In Elmore, after finding out what Kingpin did to the Loud kids, Unikitty and Master Frown plan to commit several pranks such as coloring his skin blue upon dumping blue color in his swimming pool, sticking his phone earpiece with the Kragle, and tricking him into modifying his car's controls which leads to an incident where Kingpin gets it destroyed when he insults Daffy Duck after he was rear-ended into him by Granny. Eventually, Marvin the Martian towed the crushed blue car. He told Kingpin that they didn't say anything about a blue man.

The following afternoon in the Wattersons house, the crew got very bored waiting for word from another character, while Nicole Watterson gives Hawkodile some eggnog. Somehow, Wendy Corduroy comes in and tells them that Jinx was back in the flesh. He tells them that Jinx now works for Kingpin and killed the Loud kids, only for Kingpin and his lieutenants to show up as revenge on the gang for turning him blue. The team starts fighting, as Nicole exclaims, "Take it OUTSIDE!!!" Gumball, Darwin, Anais, and Richard hear this, and Gumball asks his mom what is happening. Nicole answers with "They're fighting in my house!" On the roof, Unikitty tries to get Jinx, but Kingpin and his team get away, as Jinx tells them that this isn't over. This worries Unikitty didn't want the world to be conquered by Kingpin.

A portal opens and the two girls enter a dark, crooked forest. Dr. Fox and Star Butterfly navigated the entire forest if there are any signs of danger approaching. The zappers pop out suddenly, and start zapping Dr. Fox and Star. They dive into the water, grab some logs, and use them to bump the other zappers, Star Butterfly and Dr. Fox jump off the log and down the waterfall as the zappers look for them. There was no sign of the girl duo.

Meanwhile, the Powerpuff Team arrive in Southside Reef, which, to Blossom's horror, has been decimated by Kingpin and his lieutenants, who captured all the citizens. Oscar tells the team the truth about what happened, and the group proceed to go to Kingpin's island to stop Kingpin from taking over the world. Before the group leaves for Kingpin's island, Unikitty tells Oscar to rebuild Southside Reef.

In the Super Collider Lab, Kingpin clicks his pen in a recalling of a memory of him losing his family when he was fighting Star Butterfly at his mansion, and his family leaving him. As the memory ends, he breaks the pen. Kingpin is then called by his boss, an AI from PAL Labs named PAL, who reports to him that Star has gained consciousness, and that Unikitty's friend Dr. Fox is with her. She informs Kingpin that to get Kingpin's family back, she will kill Dr. Fox so she will die of her injuries, just like the Loud kids. Kingpin tells PAL to meet him at his Collider, and PAL responds with "Our Collider."

After Dr. Fox and Star swim to shore and crawl out of the water, they lie down onto the sand, only to find out that they were swimming to a remote island. They stand themselves up, both soaking wet. That night, the two share a campfire dinner, and find a place to sleep. The next day, Dr. Fox and Star Butterfly find some signs saying that there is a way to the Super Collider Labs. The two walk to it, but a hole on the ground opens and they slide down into the underground. The girl duo find out that the island was Kingpin's island, so they enter one of the labs in it. Dr. Fox tries to browse the entire web for answers to the death of the Loud kids. It was “to create a girl named Legion Loud using the Mind Stones, and the term ‘backwards message’, in reverse”. She tells Star that the Mind Stones were found in Royal Woods. After that, the two get knocked unconscious by an eagle named Hank. After getting tied up in ropes, they are sent over to PAL, who shows a footage of Prowler killing Star's parents Moon and River in a carriage crash, and another footage of Kingpin killing Marco by shooting him, and she also tells them that she killed Star's loved ones and friends. Star Butterfly starts crying after this, and Dr. Fox comforts her by telling her that she was sorry for the death of her parents and Marco. After untying the ropes, the two hug each other. Star Butterfly feels better, grabs one of the potions, and hands it to Dr. Fox, telling her to throw this at one of Kingpin’s lieutenants if they try to kill somebody. Dr. Fox agrees to do so as the two run off.

Meanwhile, Nicole takes the team to the Super Collider in Elmore, and transmits a message to the cartoon universes, telling them that they will battle Kingpin and restore harmony to the cartoons and bring back the life of the Loud kids. Moments later, the team starts battling Kingpin's minions and lieutenants. Puppycorn fights Kludd, Creek, and Smiler, while Richard fights Prowler. Ebony Maw tries to kill Nicole, but a potion hits him. He turns his head to Dr. Fox, and she fights Ebony Maw and other villains down. Then Beemo and Wendy defeat Ebony Maw, throwing him into the year 2019, as he freezes and flies by the Rexcelsior, although Rex Dangervest never saw it coming. Kludd is thrown into the Phineas and Ferb universe, where the farmer and his wife argue about a dead owl. Creek is then thrown back into the Trolls universe.

The final boss is Kingpin, whom the Powerpuff Girls are going to fight. As the fight goes on, Kingpin throws Blossom on a wall, but luckily, the Girls use their laser eyes to defeat him, grabbing some ropes on him and throwing him in the planet Undar of the Dryar System. Afterwards, Legion Loud fades away from existence, giving Dr. Fox and Star Butterfly a chance to let the others go, but Unikitty says that she cannot lose her. After embracing Dr. Fox with a hug, they leave. Dr. Fox and Star Butterfly try to make it to the button that deactivates the Super Collider, but Dr. Fox is fatally injured by a PAL Max Prime robot in the process. Star Butterfly, angered by what the PAL Max Prime has done to Dr. Fox, grows her regular right arm back, destroying the robot arm in the process. As she rips her skirt off, revealing that she wears blue jean shorts underneath, finally kills the PAL Max Prime robot for revenge. She tells Eric and Deborahbot5000 to take Dr. Fox's body outside, and presses the button, causing everything to turn off and explode, killing PAL in the process and flinging Star back into the water. Star Butterfly swims back to shore, picks up Dr. Fox's injured body, to meet up with the others.

The universe is safe. Peace has been restored. The bad guys are defeated, and the Eagles are arrested. The team won the battle. A seriously injured Dr. Fox is carried on Star Butterfly's arms, and Star tells them that she failed to keep her alive and that she was sorry. Puppycorn asks where Legion Loud is, then Dr. Fox answers him that she was permanently wiped from existence, because Legion died from the explosion, as the lives of the Loud kids are gone forever. She also told Star Butterfly that they failed to get the kids back, but succeeded at defeating the bad guys. A saddened Unikitty asks Dr. Fox what had happened to her. Dr. Fox answers her that she got fatally wounded by an evil robot. Dr. Fox apologizes to the group for Legion Loud's demise. Star Butterfly told Dr. Fox that she was sorry for failing to protect her, and Dr. Fox accepts her mom figure's apology by telling her that they had really good memories together. She gives her a photo of her and Star Butterfly together as a memory. Star Butterfly shed tears as she keeps the photo, then thanks Dr. Fox for being with her as her daughter figure. Unikitty felt the urge to vomit because she was going to lose Dr. Fox. Dr. Fox tells Unikitty that she can find some other scientist to replace her before passing away from the serious wounds. At Dr. Fox's funeral, most of the people of Unikingdom like Puppycorn sang Dr. Fox's goodbye. As Unikitty transforms into Sad Kitty, her singing turns into a high pitch sad gasp of breath, which turns into loud sobbing. Richard and Puppycorn bawled their eyes out as well. They were not sure how to tell Hawkodile this. As they make their way to Hawkodile crying, Puppycorn says that it is not so important for him and he needs a moment. By saying that he needs a moment, Puppycorn runs into the castle and begins sobbing in his room alone. When Hawkodile heard about Dr. Fox's death, he screamed and sobbed with Unikitty trying to comfort him as she was still in tears. The more they thought about Dr. Fox, the harder they sobbed.

A day after Dr. Fox's funeral, the Powerpuff Girls were ready to leave Unikingdom and return home to Townsville. They said goodbye to their new friends, by telling them that they will keep saving Townsville now that Kingpin is defeated. The four hug Hawkodile, saying that they were sorry for Dr. Fox's death. Star Butterfly told them that Dr. Fox will always be her best friend, and that made her feel like she is her mom figure, and Dr. Fox is Star's daughter figure. They fly over to Dr. Fox's grave and put some flowers on it. After lighting up the candles, the Girls, along with Star, depart.

The Powerpuff Girls and Star Butterfly had returned to their home in Townsville, and entered the Utonium house. They felt bad about why Dr. Fox died, and yet, they were happy that they saved the world. Bubbles said that Star Butterfly had to live with the Powerpuff Girls permanently due to the death of her parents and friend. The Girls were lucky they didn't wanna suffer another threatening crossover invasion anymore.

A day later, The Powerpuff Girls let Star Butterfly stay at the Utonium house as their adoptive sister. Emmet and his friends arrive and gift Townsville a statue of the Powerpuff Girls before the team get called by Grizz, Panda, and Ice Bear on another mission to save San Francisco to stop Mojo Jojo.

The credits then show the Powerpuff Girls continuing to fight crime and save the day while SpongeBob and Patrick get new teammates, and the "real" Sinister Six breaks Kingpin out of Undar of the Dryar System.

Cast

 * Janice Kawaye as Legion Loud
 * Cathy Cavadini as Blossom
 * Tara Strong as Princess Unikitty, Bubbles, Raven, 2016 Ben Tennyson, 2005 Ben Tennyson, Rams Rusher and Broncos Rusher
 * E.G Daily as Buttercup
 * Grey Griffin as Prince Puppycorn and Ravens Rusher
 * Kate Micucci as Dr. Fox, Velma Dinkley, Webby, Panthers Rusher and Cardinals Rusher
 * Eden Sher as Star Butterfly
 * Roger Craig Smith as Hawkodile, Richard, Diamondhead, Bills Rusher, Giants Rusher, Bengals Rusher, Saints Rusher, Chiefs Rusher, Vikings Rusher, Buccaneers Rusher, Lions Rusher and Redskins Rusher
 * Eric Bauza as Master Frown, Chet, Buhdeuce, Chromastone, Eatle, Arcticguana, Upchuck, Buzzshock, Eagles Rusher, Colts Rusher, Jaguars Rusher, Falcon Rusher, Chargers Rusher, Bears Rusher, Browns Rusher, Packers Rusher, Texans Rusher, 49ers Rusher, Dolphins Rusher, Titans Rusher, Patriots Rusher, Raiders Rusher, Jets Rusher, Steelers Rusher and Cowboys Rusher
 * H. Michael Croner as Brock, JP and Seahawks Rusher
 * Olivia Olson as Blisstina Frances Francia Mariam Alicia Utonium and Vanessa Doofenshrmitz
 * Linda Cardellini as Wendy Corduroy
 * Niki Yang as Beemo
 * Liev Schreiber as Wilson Fisk / Kingpin
 * Tom Vaughan-Lawlor as Ebony Maw
 * Ryan Kwanten as Kludd
 * Russell Brand as Creek
 * Brand also voices Creek's redeemed clone
 * Olivia Colman as PAL and Donka
 * Kathryn Hahn as Olivia Octavius / Doctor Octopus
 * Mahershala Ali as Aaron Davis / Prowler
 * Simon Cowell as himself, who is revealed to be the Prowler
 * Marvin Jones III as Tombstone
 * Joaquín Cosío as Scorpion
 * Jorma Taccone as Norman Osborn / Green Goblin
 * Josh Brolin as Thanos
 * Michael Keaton as Adrian Toomes / Vulture
 * Jake Gyllenhaal as Quentin Beck / Mysterio
 * Tom Hardy as Eddie Brock / Venom
 * Woody Harrelson as Cletus Cassidy / Carnage
 * Will Arnett as Slade
 * Alexander Polinsky as Control Freak
 * Frank Welker as Monsieur Mallah and Scooby-Doo
 * Lauren Tom as Jinx
 * Chris Wedge as Scrat and Wonderbot
 * Anna Faris as Jailbreak and Sam Sparks
 * T.J. Miller as Gene Meh, Fred, Robbie, and Tuffnut
 * James Corden as Hi-5 and Peter Rabbit
 * Catherine Taber as Lori Loud
 * Liliana Mumy as Leni Loud
 * Nika Futterman as Luna Loud and Ash Reynolds
 * Malachi Cohen as Ish Taylor
 * Johnny Yong Bosch as Troy Kang
 * Andy Aragon as Marty Stevens
 * Ogie Banks as Tua Tupola
 * Nicolas Roye as Ricky Cervantes
 * Ashlynn Chong as Ashlynn
 * Sela Hack as Sela
 * Bredia Santoro as Bredia
 * Hanna Yorke as Hanna
 * Eva Agathis as Eva
 * Charisma Kain as Charisma
 * Kiana Ledé Brown as Kiana
 * Grant Knoche as Grant
 * Matt Martinez as Matt
 * Jayna Brown as Jayna
 * Julianna Revilla as Julianna
 * Sierra Brogmus as Sierra
 * Ahnya O'Riordan as Ahnya
 * Isaiah Morgan as Isaiah
 * Cooper Hounshell as Cooper
 * Layla Stiscak as Layla
 * Olivia King as Olivia
 * Alana Gay as Alana
 * Jacob Jones as Jacob
 * Egan Keiber as Egan
 * Ayden Nguyen as Ayden
 * Shane Davis as Shane
 * Indigo Carey as Indigo
 * Lois Ellington as Lois
 * Twinkle Jaiswal as Twinkle
 * Mia McLoughlin as Mia
 * Max Kenward as Max
 * Ashton Henry-Reid as Ashton
 * Stephen Tetkowski as Stephen
 * Matthew Mercer as Sudden Death
 * Cristina Pucelli as Luan Loud
 * Asher Bishop as Lincoln Loud
 * Jessica DiCicco as Lynn Loud, Lucy Loud
 * Grey Griffin as Lana Loud, Lola Loud, Lily Loud, Burn, Arcee
 * Lara Jill Miller as Lisa Loud
 * Brian Stepanek as Lynn Loud Sr., Gorg Commander, Nugent, Boovs, and Sector Seven Agent
 * Jill Talley as Rita Loud and Karen
 * Andre Robinson as Clyde McBride
 * Izabella Alvarez as Ronnie Anne Santiago
 * Carlos PenaVega as Bobby Santiago
 * Dove Cameron as Carol Pingrey
 * Kari Wahlgren as Maggie and Gabby
 * Margot Rubin as Whitney
 * Laura Bailey as Becky
 * Romi Dames as Jackie
 * Alex Ryan as Fiona
 * Tonatiuh Elizarraraz as Miguel
 * Ariel Fournier as Mandee
 * Omar Benson Miller as 2018 Raphael
 * Josh Brener as 2018 Donatello
 * Brandon Mychal Smith as 2018 Michelangelo
 * Leslie Jones as Zeta Eagle
 * Zach Woods as Carl Eagle and Zane
 * Pete Davidson as Jerry Eagle
 * Beck Bennett as Hank Eagle, Brad Eagleburger, Launchpad McQuack, and Eric
 * Eugenio Derbez as Glenn and Alejandro Gutierrez
 * David Dobrik as Axel
 * Jojo Siwa as Kira and Jay
 * Greg Cipes as Beast Boy, 2012 Michelangelo, 2016 Stinkfly and Kevin Levin, and Tad
 * Scott Menville as Robin
 * Hynden Walch as Starfire
 * Khary Payton as Cyborg
 * Jeremy Shada as Finn
 * Robbie Daymond as SwaySway and Jesse
 * Audrey Wasilewski as Rambamboo
 * Rob Paulsen as 2012 Donatello, and Ditto
 * Sean Astin as 2012 Raphael
 * Jessica DiCicco as Zach, Lindsay Sweetwater
 * Alyson Stoner as Sam Sharp
 * Pamela Adlon as Tabby
 * Amanda McCann as Giggles
 * Haley Tju as Stella, Marcy Wu, and Alia
 * Ashley Johnson as Paige, Tulips Olsen, and Mirror Tulip
 * Mariel Sheets as Darcy Helmandollar
 * Carlos Alazraqui as Francisco, Silas
 * John DiMaggio as Chunk, Jake, Four Arms, Armodrillo
 * Georgie Kidder as Polly Pain, Haiku
 * Marlow Barkley as Sasha
 * Parsa Montezari as Amir
 * Jake Johnson as Peter B. Parker / Spider-Man
 * Shameik Moore as Miles Morales / Spider-Man
 * Robert Downey Jr. as Tony Stark / Iron Man
 * Chris Evans as Steve Rogers / Captain America
 * James Adomian and Mark Ruffalo as the Zappers, Kingpin’s minions who were previously seen in Season 3 finale of Talking Tom and friends, and forever saying the words “Bad friend!”
 * Woody Harrelson as Jake
 * Jason Sudeikis as Red
 * Josh Gad as Chuck
 * Danny McBride as Bomb and Rick Mitchell
 * Rachel Bloom as Silver (bird)
 * Nolan North as Terence, Oonski, and Space Core
 * Lil Rel Howery as Alex, Tom's Devil and Angel Shoulders, and himself
 * Bill Hader as Leonard, BB-8, and Fear
 * Sterling K. Brown as Garry
 * Tony Hale as Ross, Mime, and Forky
 * TBA as Jake
 * TBA as Jim
 * Brooklynn Prince as Zoe
 * Alma Versano as Sam-Sam (Samantha)
 * Genesis Tennon as ViVi (Vincent)
 * Ava Acres as Timothy
 * Hannibal Buress as Edward
 * Josh Engel as Brad
 * Kate McKinnon as Stella (bird)
 * Charli XCX as Willow
 * Anthony Padilla as Hal
 * Ian Hecox as Bubbles
 * Peter Dinklage as Mighty Eagle
 * Keegan Michael-Key as Judge Peckinpah
 * Thurop Van Orman as Duck
 * Nicki Minaj as Pinky
 * Awkwafina as Courtney, Sisu, and Otto
 * Gaten Matarazzo as Bubba
 * Billy Eichnner as Chef
 * Sunday Urban as Isla
 * Faith Ubran as Sophie
 * Mason Ramsey as Oilver
 * Sean Charmatz as Invisible
 * Doug the Pug as Monchi
 * Ryan Potter as Hiro Hamada
 * Scott Adsit as Baymax
 * Jason Ritter as Dipper Pines
 * Kristen Schaal as Mabel Pines
 * Alex Hirsch as Grunkle Stan, Dirk, Steve Eagle, King, Soos, Bill Cipher
 * Anthony Daniels as C-3PO
 * Jimmy Vee as R2D2
 * John Boyega as Finn
 * Daisy Ridley as Rey
 * Harrison Ford as Han Solo
 * Joonas Sutoamo as Chewbacca
 * Tom Kane as Yoda
 * Billy Dee Williams as Lando Carissian
 * Ewan McGeorger as Obi-Wan and Rodney Copperbottom
 * Mark Hamill as Luke Skywalker
 * Ben Schwartz as BB-8, Dewey, 2018 Leonardo, Banarnar, Sonic
 * Tom Hanks as Woody
 * Tim Allen as Buzz Lightyear
 * Keanu Reeves as Duke Caboom
 * Wallace Shawn as Rex
 * John Ratzenberger as Hamm
 * Blake Clark as Slinky Dog
 * Alan Tudyk as River Butterfly, the late King of Mewni and Star's mother, whom Prowler killed in a carriage crash.
 * Tudyk also voices Ludo
 * Grey Griffin as Moon Butterfly, the late Queen of Mewni and Star's mother, whom Prowler also killed.
 * Duke Cutler as Gumball
 * Christian J. Simon as Darwin
 * Kyla Rae Kowalewski as Anais
 * Teresa Gallagher as Nicole
 * Dan Russell as Richard Watterson
 * Christopher Mintz-Plaase as King Gristle Jr. and Fishlegs
 * Scott Underwood as Gaylord Robinson
 * Mike Mitchell as Miss Simian
 * Kerry Shale as Larry Needlemeyer
 * Charles Philipp as Rob
 * Hugo Harold-Harrison as Tobias Wilson
 * Jessica McDonald as Carrie Krueger
 * Mic Graves as Banana Joe
 * John C. Reilly as Wreck-It Ralph
 * Sarah Silverman as Vanellope Von Schweetz
 * Jack McBrayer as Fix-It Felix, Wander, and Toadie
 * Chris Pratt as Emmet and Rex Dangervest
 * Will Arnett as Steve and Batman
 * Michael Cera as Robin and Barry
 * Rosario Dawson as Batgirl
 * Zach Galifianakis as the Joker and Ron the B*BOT
 * Alison Brie as 2014 Unikitty
 * Charlie Day as Benny and Art
 * Nick Offerman as Metalbeard
 * Stephanie Beatriz as General Sweet Mayhem
 * Tiffany Haddish as Queen Watevra Wa'Nabi and Debbie Eagle
 * Richard Ayoade as Ice Cream Cone and Jerry B
 * Christopher Miller as Chocolate Bar
 * Will Ferrell as President Business
 * Liam Neeson as Scribble Cop
 * Morgan Freeman as Vitruvius
 * Dave Franco as Lloyd Garmadon
 * Kumail Nanjiani as Jay Walker
 * Michael Peña as Kai, Terrance, Grubber, Tito, and Luis
 * Fred Armisen as Cole and Deborahbot 5000 and KVN
 * Jackie Chan as Sensei Wu, Monkey, and Mr. Feng
 * Justin Theroux as Lord Garmadon and Dropkick
 * Pierre Coffin as the Minions
 * Brian Hull as Count "Drac" Dracula
 * Selena Gomez as Mavis
 * Andy Samberg as Jonathan
 * Asher Blinkoff as Dennis
 * David Spade as Griffin the Invisible Man
 * Steve Buscemi as Wayne
 * Zoe Berri as Winnie
 * Brad Abrell as Frankenstein
 * Fran Drescher as Eunice
 * Abbi Jacobson as Katie Mitchell and Nya
 * Maya Rudolph as Linda Mitchell, Matilda, and Smiler
 * Michael Rianda as Aaron Mitchell
 * Mr. Lawrence as Plankton
 * Tom Kenny as Spongebob Squarepants, Flain, Seismo, Teslo, Sumo, Gary, and Talking Hank
 * Bill Fagerbakke as Patrick
 * Will Smith as Oscar and Lance Sterling
 * Renee Zellweger as Angie and Vanessa Bloome
 * Catherine Winder as Billy the Sign
 * Kellen Goff as Freddy Fazbear, Funtime Freddy, Fredbear, Glamrock Freddy, Daycare Attendant
 * Heather Masters as Chica the Chicken, Circus Baby, Glamrock Chica
 * Joe Gaudet as Bonnie the Bunny
 * Cameron Miller as Montgomery Gator
 * Marta Svetek as Vanny, Roxanne Wolf
 * S.T.A.F.F. Bots as "themselves"
 * Reid Scott as Turbo
 * Amir Talai as Skidmark
 * Phil LaMarr as Smoove Move, Flurr, Chomly, Tentro
 * Michael Patrick Bell as White Shadow
 * Patton Oswalt as Max and Nom Nom
 * Eric Stonestreet as Duke
 * Albert Brooks as Marlin and Tiberius
 * Hayden Rolence as Nemo
 * John Cena as Ferdinand
 * Anthony Anderson as Bones
 * Bobby Cannavale as Valiente
 * Peyton Mainning as Guapo
 * Silas McDonnell as Suction Cup Man
 * Zach Fuller as Guy Business
 * Robin Nelson as Officer Paul Ease
 * Owen Wilson as Lightning McQueen and Reggie
 * Larry the Cable Guy as Mater
 * Billy Crystal as Mike Wazowski
 * John Goodman as James P. Sullivan
 * Peter Cullen as Optimus Prime
 * Dylan O'Brien as Bumblebee
 * Andrew Morgado as Cliffjumper
 * Dennis Singletary as Ratchet
 * Steve Blum as Wheeljack
 * Kevin Michael Richardson as Bulkhead
 * Ryan Reynolds as Detective Pikachu and 2013 Turbo
 * Justice Smith as Tim Goodman and Marc
 * Collen O'Shaughnessey as Tails
 * Ellen McLain as GLaDOS
 * Stephen Merchant as Wheatley
 * Jamie Foxx as Joe Gardner and Nico
 * Tina Fey as 22 and Roxanne Ritchi
 * Ed Asner as Carl Fredricksen (archival recordings)
 * Jordan Nagai as Russell
 * Amy Poehler as Joy, Sally O'Malley-McDodd, and Jenny
 * Phyllis Smith as Sadness
 * Lewis Black as Anger
 * Mindy Kaling as Disgust
 * Dana Davis as Kelly
 * Abby Elliott as Janna
 * Adam McArthur as Marco Diaz
 * Esmé Bianco as Eclipsa Butterfly
 * Justin Roiland as Rick and Morty
 * Colin Hanks and James Adomian as Talking Tom and Ben (Tom and Ben News)
 * Mr. Doug Lawrence as Plankton and Realistic Fish Head
 * Clancy Brown as Mr. Krabs
 * Rodger Bumpass as Squidward Tentacles
 * Eric Edelstein as Grizz
 * Bobby Moynihan as Panda and Louie
 * Demetri Martin as Ice Bear
 * Charlyne Yi as Chloe
 * Zach Callison as Steven Universe
 * Estelle as Garnet
 * Michaela Dietz as Amethyst
 * Deedee Magno as Pearl
 * William Shatner as James T. Kirk
 * Leonard Nimoy as Spock (archival recordings)
 * Lisa Schwartz as Talking Angela
 * Dan Povenmire as Dr. Heinz Doofenshmirtz
 * John Viener as Norm
 * Vincent Martella as Phineas
 * Thomas Sangster as Ferb
 * Brenda Song as Anne Boonchuy
 * Justin Felbinger as Sprig Plantar
 * Amanda Leighton as Polly Plantar
 * Bill Farmer as Hopediah "Hop Pop" Plantar and Goofy
 * Sarah Nicole Robles as Luz Noceda
 * Wendie Malick as Eda Clawthorne
 * Chris Hughton as Cricket Green
 * Marieve Herington as Tilly Green
 * Artemis Pebdani as Gramma Green
 * Bob Joles as Bill Green
 * Zeno Robinson as Remy Remington
 * Sarah Nicole Robles as Luz Noceda
 * Wendie Malick as Eda Clawthorne
 * David Tennant as Scrooge McDuck, Angus (bull), and Angus (human)
 * Tony Anselmo as Donald Duck
 * Paget Brewster as Della Duck
 * Kimiko Glenn as Lena, Peni Parker, Horse, Izzy Moonbow, Auntie Mei, and Margot
 * Jim Rash as Gyro Gearloose
 * Toks Olagundoye as Mrs. Beakley
 * Lin-Manuel Miranda as Gizmoduck and Vivo
 * Demi Lovato as Smurfette
 * Joe Manganiello as Hefty Smurf
 * Jack McBrayer as Clumsy Smurf
 * Danny Pudi as Brainy Smurf and Huey
 * Mandy Patinkin as Papa Smurf
 * Kelly Clarkson as Moxy and Leah
 * Blake Shelton as Ox and Earl
 * Pitbull as Uglydog and Bufo
 * Wanda Sykes as Wage, Bessie, and Granny
 * Wang Leehom as Lucky Bat
 * Gabriel Iglesias as Babo and Speedy Gonzales
 * Emma Roberts as Wedgehead
 * Seth MacFarlane as Peter Griffin, Brian Griffin, and Stewie Griffin
 * Seth Green as Chris Griffin, and 2012 Leonardo
 * Dan Castellaneta as Homer Simpson
 * Nancy Cartwright as Bart Simpson
 * Steven Williams as Francis Williams
 * Tim Hautekiet as Edd
 * Thomas Ridgewell as Tom
 * Matt Hargreaves as Matt
 * Tord Larsson as Tord
 * Brock Baker as Eduardo
 * Eddie Bowley as Jon
 * Benjamin Rudman as Mark
 * Scott Cawthon as Phone Guy
 * Dane Boedigheimer as Annoying Orange and Pear
 * Lovell Stanton as Charleyyy
 * Chris Netherton as Brooklyn T. Guy
 * Lance Thirtyacre as Mr. Goodman
 * Logan Thiryacre as Mario
 * Kaleb Sherretz as Player and Veteran
 * Ryan Stewart as Gentleman, Captain, Stoner, and Blue
 * Cory Crater as Mr. Cheese and Bro
 * Bronson Lasseter as Mr. Egg
 * Abigail Turner as Angel, Mother, and Noob
 * Joe Jowett as B Day
 * Katie Spradlin as Gnome
 * Ed Helms as Captain Underpants
 * Kevin Hart as George Beard and Snowball
 * Thomas Middleditch as Harold Hutchins
 * Channing Tatum as Superman
 * Jonah Hill as Green Lantern and Snotlout
 * Cobie Smulders as Wonder Woman
 * Jason Momoa as Aquaman
 * Todd Hansen as Gandalf
 * Brian Tyree Henry as Jefferson Davis
 * Henry also voices Dancarino
 * Nicole Byer as Valentina
 * J.K. Simmons as J. Jonah Jameson, Mayor Lionheart, and Klaus
 * Matthew Lillard as Shaggy Rogers
 * Mark Wahlberg as Blue Falcon
 * Ken Jeong as Dynomutt
 * Kiersey Clemons as Dee Dee Skyes
 * LeBron James as himself
 * Michael B. Jordan as himself
 * Philip Solomon as Craig
 * Georgie Kidder as Kelsey
 * Parker Simmons as Mao Mao
 * Griffith Kimmins as Badgerclops
 * Lika Leong as Adorabat
 * Diego Molano as Victor
 * Sean-Ryan Petersen as Valentino
 * Motserrat Hernandez as 2016 Gwen Tennyson and 2005 Gwen Tennyson
 * Yuri Lowenthal as 2008 Ben Tennyson, 2010 Ben Tennyson, 2012 Ben Tennyson, Gax, Feedback
 * David Kaye as 2016 Max Tennyson, 2005 Max Tennyson, Shock Rock, Shocksqautch, Gravattck, Swampfire, Humungousaur
 * Paul Eiding as Eye Guy
 * Dee Bradley Baker as Rath, 2005 Stinkfly, AmpFibian, Clockwork, Goop, NRG, WaterHazard, Echo Echo, Lodestar, Big Chill, Perry the Platypus
 * Fred Tatasciore as 2005 Ripjaws, Ben 10,000, Jawg, Slumbo, Kraw
 * Bumper Robinson as Terraspin, Flamzer, Wizwuz, Glurt, Footi, and Bloxx
 * David Hornsby as 2016 Wildvine
 * David Sobolov as Upgrade
 * Josh Keaton as XLR8
 * Todd Haberkorn as Slapback and Grey Matter
 * Travis Willingham as Cannonbolt
 * Daryl Sabara as 2016 Heatblast and 2005 Heatblast
 * Vyvan Pham as Ship
 * Corey Burton as Brainstorm
 * Maria Bamford as Scorpi, Nora Beady, and Talking Ginger
 * Alan Ituriel as Black Hat
 * Todd Asayer as Dr. Flug
 * Melaney Sems as Demenica
 * Mark Edward Fischbach as 5.0.5
 * Jess Harnell as Zaptor, Shuff
 * David P Smith as Zorch, Crazy Joe, and Krader
 * Carlos Alazraqui as Mesmo and Torts
 * Billy West as Lunk, Gobba, Balk
 * Maddie Tatlor as Glomp and Hoogi
 * Spencer Rothbell as Clarence
 * Sean Giambrone as Jeff
 * Jeremy Rowley as Bunsen
 * Ben Giroux as Mikey Munroe
 * Cooper Barnes as Captain Man
 * Jace Norman as Kid Danger
 * Lucas Grabeel as Pinkly Malinky
 * Diamond White as Babs Byuteman
 * Nathan Kress as JJ Jameson
 * Richardo Hurtado as High Five
 * Monica Ray as Miko
 * Traci Paige Johnson as Blue
 * Joshua Dela Cruz as Josh
 * Steve Burns as Steve
 * Donovan Patton as Joe
 * Bella Ramsey as Hilda
 * Ramses Hardiker as Alfur Aldric
 * Ameerah Falzon-Ojo as Frida
 * Gary Schwartz as Heavy
 * Rick May as Soldier (archival recordings)
 * Grant Goodeve as Engineer
 * Robin Atkin Downes as Medic
 * Nathan Vetterlein as Scout
 * Peter Serafinowicz as the Tick
 * Griffin Newman as Arthur Everest
 * Justin Timberlake as Branch
 * Ron Funches as Cooper
 * Kunal Nayyar as Guy Diamond
 * Kenan Thompson as Tiny Diamond
 * Anthony Ramos as King Trollex
 * Paul Giamatti as 2013 Chet
 * Tom McGrath as Skipper
 * Chris Miller as Kowalski
 * Conrad Vernon as Rico
 * Christopher Knights as Private
 * Ben Stiller as Alex
 * Chris Rock as Marty
 * Alec Baldwin as Boss Baby
 * James Marsden as Tim Templeton and Tom Wachowski
 * Oscar Isaac as Gomez Addams
 * Chloë Grace Moretz as Wednesday Addams
 * Javon Walton as Pugsley Addams
 * Nick Kroll as Uncle Fester
 * Snoop Dogg as Cousin Itt
 * Jimmy Wang as Din
 * John Cho as Long
 * Jay Baruchel as Hiccup
 * Gerald Butler as Stoick the Vast
 * Randy Thom as Toothless, Light Fury, and Sandy Crood
 * Kristen Wiig as Ruffnut and Brenda
 * Djimon Hounsou as Drago
 * F. Murray Abraham as Grimmel
 * Martin Scorsese as Sykes
 * Robert de Niro as Don Lino
 * Jack Black as Po, R.L. Stine, and Lenny
 * Bryan Cranston as Li
 * Dustin Hoffman as Master Shifu
 * James Hong as Mr. Ping
 * Seth Rogen as Mantis, Frank, and B.O.B.
 * David Cross as Crane
 * Lucy Liu as Viper
 * Jim Parsons as Oh
 * Steve Martin as Captain Smek and Mr. Chairman
 * Matt L. Jones as Kyle, a Boov police officer
 * Zach Braff as Chicken Little
 * Steve Zahn as Runt
 * Tommy Lee Jones as HAL 9000
 * Candice Bergen as SAL 9000
 * Doug Walker as Nostalgia Critic
 * Huck Milner as Dash
 * Craig T. Nelson as Mr. Incredible
 * Samuel L. Jackson as Frozone and Nick Fury
 * Patrick Stewart as Poop
 * Sean Hayes as Steven
 * Steven Wright as Mel Meh
 * Gene Simmons as himself
 * Paul Stanley as himself
 * Ace Frehley as himself
 * Peter Criss as himself
 * Mike Myers as Shrek
 * Eddie Murphy as Donkey
 * Antonio Banderas as Puss in Boots and Burger Beard
 * T.J. Storm as Godzilla
 * Michael Douglas as Guy-I-Am
 * Adam DeVine as Sam-I-Am
 * Ginnifer Goodwin as Judy Hopps
 * Jason Bateman as Nick Wilde
 * Dwayne Johnson as Maui
 * J.G. Quintel as Mordecai, Hi-Five Ghost
 * William Salyers as Rigby
 * Sam Marin as Benson, Muscle Man
 * Mark Hamill as Skips
 * Jacob Tremblay as Luca
 * Jack Dylan Grazer as Alberto and Barney
 * Olan Rogers as Gary Goodspeed and Mooncake
 * Tika Sumpter as Quinn
 * Coty Galloway as Avacato
 * Adam Sopp as Harry Potter
 * Rupert Grint as Ron Wealsey
 * Alice Keenan as Hermione Granger
 * Elliot Smith as Oscar
 * Oona Laurence as Hedgehog
 * Juila Pott as Susie
 * Ramone Hamilton as Max
 * Sam Lavagnino as Pepper
 * Indie Nameth as Lucy
 * Nikki Castillo as Betsy
 * Alexia Nisenson as Alexa
 * Chris Hemsworth as Thor
 * Mark Ruffalo as Hulk
 * Kevin Farley as Crab
 * Dan Lloyd as the Villagers
 * Nola Klop as Poppy Playtime
 * Zachary Preciado as Huggy Wuggy, Bunzo Bunny, and Boogie Bot
 * Eisle Lovelock as Mommy Long Legs and Uzi
 * Emily Frongillo as Kissy Missy and Daisy
 * Micah Preciado as PJ Pug-a-pillar and Bron
 * Avalon Preciado as Candy Cat
 * Rihanna Moushall as Cat-Bee
 * Jeremy Renner as Hawkeye
 * Catherine Cavadini as female newscaster who announces on the news about Dr. Fox's death. and the news about the undoing of the kingpin invasion

Although Lou, Tuesday, Kitty, and Lydia from the UglyDolls movie make cameos during Emmet’s runaway, they have no dialogue.

Emperor Maximus from Playmobil: The Movie makes a cameo as a driver whom Kingpin almost collides with. His actor, Adam Lambert, is uncredited.

The other Unikitty characters except for Hawkodile sing a sad song about Dr. Fox's death. Their singing devolves into a high pitch sad gasp of breath before crying as loud as they can.

Tim Willoughby makes a cameo as a pedestrian during Red’s runaway whom the Prowler almost runs over. However, he has no dialogue, he just makes a noise.

Two psychedelic murals of Pig and Otis appear during the Prowler chase scene.

Songs

 * The Other Side - SZA, Justin Timberlake (Note: This plays when Spongebob narrates the prologue.)
 * The Avengers (from "Avengers: Infinity War") - Alan Silvestri (Note: This plays during the opening credits)
 * Sunflower - Post Malone, Swae Lee (Note: This plays during the Loud kids' introduction)
 * This Is War - Ben Kweller (Note: This plays when Lincoln and his bike destroy everything in Royal Woods.)
 * Finally Free - Niall Horan (Note: This plays during the Loud kids' meltdown)
 * You Will Always Find Me In Your Heart - Shaley Scott (Note: This plays after Lincoln & his sisters die from their injuries, get taken back to Royal Woods & buried before Kingpin digs them up so he could create Legion.)
 * U Can't Touch This - MC Hammer (Note: This plays on a segment in the Frown Town scene.)
 * Agua - Tainy, J Balvin (Note: This plays after the camera pans down to Bird Island Activity Center.)
 * It's A Jungle Out Here - Philip Lawrence (Note: This plays when Unikitty and Master Frown pull a prank on Kingpin and turn him blue)
 * Blue (Da Ba Dee) - Eiffel 65 (Note: This plays when Kingpin tampers the controls to his car.)
 * I Don't Wanna - Scarlett Johansson, Beck Bennett (Note: This plays when King Gristle drives off and prepares to bump Kingpin's car)
 * Randall's Attack - Randy Newman (Note: This plays when King Gristle is about to bump Kingpin's car)
 * Drop That - Jacob Plant (Note: This plays during the Wattersons House fight)
 * Bouncy House - Flo Rida (Note: This plays when Poppy and her friends ride the Caterbus to Kingpin's island.)
 * Rockabye - Clean Bandit, Sean Paul, Anne-Marie (Note: This plays during Dr. Fox and Star Butterfly's entry to Elmore before entering the Super Collider.)
 * Towards The Sun - Rihanna (Note: This plays when Dr. Fox and Star Butterfly try to deactivate the Super Collider only for Dr. Fox to be injured by the PAL Max robot.)
 * I Fly - Galantis, Faouzia (Note: This plays when Emmet and his friends gift Townsville a statue of Townsville.)

End Credits Music

 * Broken & Beautiful - Kelly Clarkson
 * On Me - Ava Max, Thomas Rhett, Kane Brown
 * The Penguins of Madagascar - Lorne Balfe
 * Roomies - Heitor Pereira

Trivia

 * Kingpin's screaming when calling the Eagle Guards is similar to Drago's scream from How To Train Your Dragon 2.
 * The killing of Moon and River Butterfly is similar to the killing of Tony Stark's parents from Captain America: Civil War.

Transcript
Main article: The Powerpuff Girls: Crossover War/Transcript